A novel statistical method predicts mutability of the genomic segments of the SARS-CoV-2 virusResearch Article Published on 2022-12-132022-10-29 Journal: Qrb Discovery [Category] COVID-19, [키워드] affected antiviral drugs approach candidate coding regions codon conserved correlated correlation determine develop disease distribution effective epitope Frequency genomic identify immunogenic peptide large-scale analysis mutability offer overcome pandemic pathogenesis of SARS-CoV-2 predict predicted Protein SARS-CoV-2 SARS-CoV-2 virus SARS-CoV2 scientist sequence Seven spike glycoprotein statistical statistical analysis target the SARS-CoV-2 virus treatments for COVID-19 Vaccine viral genome viral mutation whole genome whole genome sequence Word Ranking [DOI] 10.1017/qrd.2021.13 PMC 바로가기 [Article Type] Research Article
Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot studySARS-COV-2 감염 및 급성 신장 손상 마커에 의해 유도 된 변경된 신장 기능 COVID-19 환자의 생존 결과를 예측합니다 : 전향 적 파일럿 연구Article Published on 2022-12-012022-08-31 Journal: Renal failure [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute kidney Acute kidney injury adjusted Advancing age Altered Analysis association Biomarker chronic Chronic kidney disease collaboration Comorbidities Comorbidity Control coronavirus disease Coronavirus disease 2019 covariate covariates COVID-19 COVID-19 patient COVID-19 patients creatinine Cumulative rates cystatin C death demonstrated elevated examined group groups Hospitalized ICU intensive care intensive care unit investigated Kaplan-Meier method kidney kidney damage Kidney disease Kidney function Kidney function tests Kidney injury literature marker morbidity multivariable Cox regression outcome participant pilot study predict Predictive Predictive value Proteinuria retained risk factor Risk factors SARS-COV-2 infection serum serum creatinine Sex significant difference statistically subject survival survival analysis survival analysis. the Kaplan-Meier method Treatment Urine with COVID-19 [DOI] 10.1080/0886022X.2022.2032743 PMC 바로가기 [Article Type] Article
A hybrid random forest deep learning classifier empowered edge cloud architecture for COVID-19 and pneumonia detectionResearch article Published on 2022-12-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 치료기술, [키워드] Accuracy Affect Algorithm Classifier cloud computing complex computation conducted COVID-19 COVID19 CT scan dataset datasets deep deep learning detect diagnose effective Efficiency evaluate False positives forest global pandemic Healthcare industry heat Heat Transfer Search algorithm identify immunization inefficient Interaction less lung CT scan methodology offer outcomes overcome Patient Pneumonia predict PROTECT random Random forest resource Support the patient virus Web services X-ray [DOI] 10.1016/j.eswa.2022.118227 [Article Type] Research article
Predict, prevent and manage moral injuries in Canadian frontline healthcare workers and leaders facing the COVID-19 pandemic: Protocol of a mixed methods studyResearch article Published on 2022-12-012022-10-05 Journal: SSM - Mental Health [Category] 바이오마커, [키워드] addition adjusted analysis Biomarker Biomarkers blood sample build collected condition contribute COVID-19 COVID-19 crisis COVID-19 pandemic develop disease emotional event expand frontline healthcare worker generate group Health healthcare healthcare worker Healthcare workers identify Inflammation Injury knowledge mental health Moral Moral injuries observé occur Occurrence participant predict predictor Prevent protocol psychosocial stressor Psychosocial stressors at work Quantitative Quantitative data questionnaire recommendation reduce Research risk Risk factors severity Stress Stressor [DOI] 10.1016/j.ssmmh.2022.100124 [Article Type] Research article
Humoral response and safety of the third booster dose of BNT162b2 mRNA COVID-19 vaccine in patients with multiple sclerosis treated with ocrelizumab or fingolimodArticle Published on 2022-12-012022-11-15 Journal: Journal of Neurology [Category] COVID19(2023년), SARS, 진단, [키워드] binding antibody unit BNT162b2 mRNA BNT162b2 mRNA vaccine booster dose collected Control COVID-19 COVID-19 vaccine dose expressed fingolimod HCs humoral Humoral response IgG IgG antibody IgG level Laboratory mRNA mRNA vaccine Multiple multiple sclerosis Ocrelizumab Ocrelizumab. of BNT162b2 Patient positive predict quantified reported SARS-CoV-2 sclerosis serum sample severe adverse event socio-demographic threshold Tolerability treated Trimeric spike protein Vaccine vaccine dose variable [DOI] 10.1007/s00415-022-11296-4 PMC 바로가기
Beyond COVID-19: Do biothermodynamic properties allow predicting the future evolution of SARS-CoV-2 variants?Research article Published on 2022-12-012022-10-05 Journal: Microbial Risk Analysis [Category] 변종, [키워드] Analysis binding biological property changes in COVID-19 pandemic driving Epidemiological study Evolution Evolution of SARS-CoV-2 Gibbs energy of binding Gibbs energy of growth growth Mechanistic model MERS-CoV Mutation new strain new virus Occurrence pandemic parameter performed predict risk SARS CoV-2 SARS-CoV statistical Strains the SARS-CoV-2 variants of SARS-CoV-2 Virus-host interaction viruses [DOI] 10.1016/j.mran.2022.100232 [Article Type] Research article
Surveillance of SARS-CoV-2 in nine neighborhood sewersheds in Detroit Tri-County area, United States: Assessing per capita SARS-CoV-2 estimations and COVID-19 incidenceResearch article Published on 2022-12-012022-10-05 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] 5-hydroxyindoleacetic acid acute respiratory syndrome Assessing Biomarker Biomarkers collected Community Comparisons Concentration coronavirus correlation COVID-19 COVID-19 burdens COVID-19 case COVID-19 incidence creatinine cumulative demographic characteristics demographics Detroit Detroit Tri-County area Epidemiology genomic indicate Infection N1 and N2 nine normalized parameter polymerase chain Population predict quantified reduced RNA concentration SARS-CoV-2 SARS-CoV-2 RNA normalization screened selected suggested the disease transcriptase wastewater Wastewater-based epidemiology with COVID-19 xanthine [DOI] 10.1016/j.scitotenv.2022.158350 [Article Type] Research article
Intention to participate in COVID-19 vaccine clinical trials in May 2021: a cross-sectional survey in the general French populationArticle Published on 2022-11-302022-11-16 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval adjusted Attitude Attitudes Clinical research clinical trial conducted contribute COVID 19 COVID-19 COVID-19 vaccination COVID-19 vaccine cross-sectional cross-sectional survey Factor female gender France French Government Health healthcare worker immunization increase in Intention media new SARS-CoV-2 Participation predict reduction in risk severe COVID-19 Trial trial. vaccination Vaccine vaccine availability variant [DOI] 10.1080/21645515.2022.2072630 PMC 바로가기
Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug DevelopmentArticle Published on 2022-11-142022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] binding binding site Chemical chemotypes Comprehensive Consensus COVID19-NMR development drug drug design Drug discovery fragment fragment screening functional identify International Intervention Ligand NMR NMR spectroscopy novel performed predict protease Protein Proteins proteome protocol provide public health RNA genome SARS-CoV-2 SARS-CoV-2. Screening Space the SARS-CoV-2 Vaccines variant variants of concern was used [DOI] 10.1002/anie.202205858 PMC 바로가기
High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasoneArticle Published on 2022-11-052022-11-15 Journal: Respiratory Research [Category] SARS, 바이오마커, [키워드] Admission association Biomarker Biomarkers Blood level Clinical management Control correlated covariates COVID-19 COVID-19 patient COVID-19 patients death Determination Dexamethasone died disease severity elevated Follow-up greater host inflammatory response IL-6 increased risk independent Infection Inflammation investigated Mortality NEWS2 Patient patient population patients patients treated Pearson positive positive individual predict prognostic RAGE receptor reduce risk SARS-CoV-2 score second wave significantly lower sRAGE. subject Teaching treated Treatment university [DOI] 10.1186/s12931-022-02220-5 PMC 바로가기